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The accumulation of amyloid- (A) is a pathological hallmark of AD, with A being produced through the cleavage of amyloid precursor protein (APP) by -and -secretases, generating peptides of A of varying length ( -secretasewith one missense mutation (Val97Leu, PS1V97L) formed abundant A oligomers (Zhang et al., 2014), produced cognitive deficits, and exhibited cellular oxidative stress markers ( These amyloid oligomers also contribute to the neuroinflammatory signatures of neurodegenerative diseases

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Thus, we constructed two cohorts

Archives of Toxicology

Moreover, Se-enriched green onion and broccoli also showed beneficial effects in human clinical trials (105, 106)